2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

Base Information

Chemical Name:2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine
CAS No.:1026799-01-8
Molecular Formula:C₂₅H₂₄N₂O₄
Molecular Weight:416.477
Hs Code.:

Synonyms:2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

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Chemical Property of 2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

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Technology Process of 2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

There total 9 articles about 2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₆N₂O₆

: 1026799-01-8
2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

Guidance literature:: With hydrogen; 10percent Pd/C; In methanol; for 12h;
DOI:10.1021/jm0100638

Reference yield:

: 14562-10-8
2-hydroxy-3-phenylbenzaldehyde

: 1026799-01-8
2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: DIEA / dimethylformamide / 2 h

2.1: (1-diazo-2-oxopropyl)phosphoric acid dimethyl ester / methanol

3.1: Pd(PPh₃)2Cl₂; Et₃N / dimethylformamide / 0.5 h

3.2: 23 percent / CuI / dimethylformamide / 3 h

4.1: aq. NH₂OH / ethanol / 2.5 h / Heating

5.1: tetrahydrofuran / 0.5 h

6.1: H₂ / 10percent Pd/C / methanol / 12 h

With (1-diazo-2-oxopropyl) dimethyl phosphate; bis-triphenylphosphine-palladium(II) chloride; hydrogen; hydroxylamine; triethylamine; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0100638

Reference yield:

: 2296-23-3
2-iodo-4-cyanophenol

: 1026799-01-8
2-[2-(2-methoxy-ethoxymethoxy)-biphenyl-3-yl]-benzofuran-5-carboxamidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd(PPh₃)2Cl₂; Et₃N / dimethylformamide / 0.5 h

1.2: 23 percent / CuI / dimethylformamide / 3 h

2.1: aq. NH₂OH / ethanol / 2.5 h / Heating

3.1: tetrahydrofuran / 0.5 h

4.1: H₂ / 10percent Pd/C / methanol / 12 h

With bis-triphenylphosphine-palladium(II) chloride; hydrogen; hydroxylamine; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0100638