3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide
CAS No.:1418274-49-3
Molecular Formula:C₃₁H₂₇Cl₃N₂O₆S
Molecular Weight:661.99
Hs Code.:

Synonyms:3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

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Chemical Property of 3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

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Technology Process of 3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

There total 13 articles about 3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 3144-09-0
methanesulfonamide

: 1418274-47-1
3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)benzoic acid

: 1418274-49-3
3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 30 ℃;

Reference yield:

: 946426-89-7
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

: 1418274-49-3
3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 21 h / 20 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water / 72 h / 35 °C

3.2: pH 6

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 30 °C

With dmap; n-butyllithium; di-isopropyl azodicarboxylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; toluene;

Reference yield:

: 1268245-50-6
4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

: 1418274-49-3
3-((1s,3s)-3-(2-chloro-4-((5-cyclopropyl-3-(2.6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxycyclobutyl)-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 60 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water / 72 h / 35 °C

3.2: pH 6

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 30 °C

With dmap; n-butyllithium; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide;