4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Base Information

Chemical Name:4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole
CAS No.:1268245-50-6
Molecular Formula:C₁₃H₁₀Cl₃NO
Molecular Weight:302.588
Hs Code.:
Mol file:1268245-50-6.mol

Synonyms:4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Suppliers and Price of 4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole
50mg
$ 60.00

Chemenu
4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole 95+%
25g
$ 348.00

American Custom Chemicals Corporation
4-(CHLOROMETHYL)-5-CYCLOPROPYL-3-(2,6-DICHLOROPHENYL)-1,2-OXAZOLE 95.00%
5MG
$ 450.72

AK Scientific
4-(Chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole
1g
$ 174.00

Total 16 raw suppliers

Chemical Property of 4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Chemical Property:

Boiling Point:422.5±45.0 °C(Predicted)
PKA:-4.62±0.50(Predicted)
Density:1.438±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

4-(Chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description 4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole is a heterocyclic derivative, which can be used as a pharmaceutical intermediate and used in pharmaceutical experimental research.

Technology Process of 4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

There total 7 articles about 4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 946426-89-7
4-(hydroxymethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

: 1268245-50-6
4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 83-38-5
2,6-dichlorobenzaldehyde

: 1268245-50-6
4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 90 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

3: triethylamine / 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: thionyl chloride; 1,2,3-Benzotriazole / dichloromethane / 0 - 20 °C

With 1,2,3-Benzotriazole; N-chloro-succinimide; thionyl chloride; hydroxylamine hydrochloride; diisobutylaluminium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1020569-65-6
ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate

: 1268245-50-6
4-(chloromethyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: thionyl chloride; 1,2,3-Benzotriazole / dichloromethane / 0 - 20 °C

With 1,2,3-Benzotriazole; thionyl chloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;