N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Base Information

Chemical Name:N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide
CAS No.:628318-91-2
Molecular Formula:C₄₅H₇₀N₆O₁₄
Molecular Weight:919.083
Hs Code.:

N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Synonyms:N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Suppliers and Price of N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

There total 9 articles about N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 117800-65-4
N-Allyloxycarbonyl-L-asparagin-saeure-α-tert-butylester

: 628318-90-1
N-[(2SR,5S)-2-[N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-4-oxo-7-methyloctanoyl]-L-leucinamide

: 628318-91-2
N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jo034837z

Reference yield:

: 52716-49-1
N-((3S)-1-bromo-2-oxo-5-methyl-3-hexyl)-t-butoxycarboxamide

: 628318-91-2
N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

1.2: 70 percent / tetrahydrofuran / 1.5 h

2.1: NaBH₄ / methanol; 2-methoxy-ethanol / 0.33 h

2.2: 51 percent / DMAP / CH₂Cl₂ / 24 h

3.1: 89 percent / Sn(OAc)2; (i-Pr)2NEt / dimethylformamide / 17 h / 80 °C

4.1: H₂; AcOH / PtO₂ / 5 h / 20 °C

5.1: 59 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 3 h

6.1: 96 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide / 48 h

7.1: 82 percent / AcOH / H₂O / 96 h / 25 °C

8.1: 79 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂; dimethylformamide / 3 h

With dmap; sodium tetrahydroborate; hydrogen; tin(II) acetate; sulfur trioxide pyridine complex; sodium hydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; 2-methoxy-ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo034837z

Reference yield:

: 630046-94-5
methyl (2SR,5S)-5-[N-(tert-butoxycarbonyl)amino]-2-cyano-7-methyl-4-oxooctanoate

: 628318-91-2
N-[(2SR,5S)-2-[O-[(3S)-3-(N-allyloxycarbonylamino)-4-(tert-butoxycarbonyl)butanoyl]-N-benzyloxycarbonylamino-L-threonylaminomethyl]-5-[N-(tert-butoxycarbonyl)amino]-7-methyl-4-oxo-octanoyl]-L-leucinamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaBH₄ / methanol; 2-methoxy-ethanol / 0.33 h

1.2: 51 percent / DMAP / CH₂Cl₂ / 24 h

2.1: 89 percent / Sn(OAc)2; (i-Pr)2NEt / dimethylformamide / 17 h / 80 °C

3.1: H₂; AcOH / PtO₂ / 5 h / 20 °C

4.1: 59 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 3 h

5.1: 96 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide / 48 h

6.1: 82 percent / AcOH / H₂O / 96 h / 25 °C

7.1: 79 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂; dimethylformamide / 3 h

With dmap; sodium tetrahydroborate; hydrogen; tin(II) acetate; sulfur trioxide pyridine complex; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In methanol; dichloromethane; 2-methoxy-ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo034837z