(3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

Base Information

Chemical Name:(3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide
CAS No.:1175001-16-7
Molecular Formula:C₂₄H₂₇Cl₂N₇O₅
Molecular Weight:564.428
Hs Code.:

(3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

Synonyms:(3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

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Chemical Property of (3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

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Technology Process of (3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

There total 1 articles about (3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 791780-06-8
3-(3,4-dichloro-phenoxy)-azetidine

: 120225-75-4
2-chloro-2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide

: 1175001-16-7
(3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

Guidance literature:: With 1-methyl-pyrrolidin-2-one; at 165 ℃;

Reference yield:

: 1175001-16-7
(3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

: 76-05-1
trifluoroacetic acid

: (2R,3R,4S,5R)-5-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide trifluoroacetate

Guidance literature:: (3aS,4S,6R,6aR)-6-{6-amino-2-[3-(3,4-dichloro-phenoxy)-azetidin-1-yl]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide; With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 24h;

trifluoroacetic acid; In water; acetonitrile;