6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

Base Information

Chemical Name:6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin
CAS No.:1154758-85-6
Molecular Formula:C₅₂H₇₄N₈O₂₁
Molecular Weight:1147.2
Hs Code.:

Synonyms:6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

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Chemical Property of 6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

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Technology Process of 6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

There total 13 articles about 6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1154758-44-7
2',3-diPNZ-1-((R)-3-(tert-butoxycarbonylamino)-2-hydroxy-propionyl)-3''-Boc-sisomicin

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1154758-85-6
6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

Guidance literature:: 2',3-diPNZ-1-((R)-3-(tert-butoxycarbonylamino)-2-hydroxy-propionyl)-3''-Boc-sisomicin; Cyclopropanecarboxaldehyde; In N,N-dimethyl-formamide; for 2.5h; Molecular sieve;

With sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; at 0 ℃; for 1h;

With water; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 32385-11-8
sisomicin

: 1154758-85-6
6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc diacetate / methanol

1.2: 3 h

2.1: tetrahydrofuran; N,N-dimethyl-formamide

3.1: tetrahydrofuran; methanol / 3 h

4.1: methanol; ammonia; water / 18 h / 20 °C

5.1: N,N-dimethyl-formamide / 2.5 h / Molecular sieve

5.2: 1 h / 0 °C

With methanol; zinc diacetate; ammonia; water; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 69888-89-7
2,5-dioxopyrrolidin-1-yl (4-nitrobenzyl) carbonate

: 1154758-85-6
6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc diacetate / methanol

1.2: 3 h

2.1: tetrahydrofuran; N,N-dimethyl-formamide

3.1: tetrahydrofuran; methanol / 3 h

4.1: methanol; ammonia; water / 18 h / 20 °C

5.1: N,N-dimethyl-formamide / 2.5 h / Molecular sieve

5.2: 1 h / 0 °C

With methanol; zinc diacetate; ammonia; water; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;