69888-89-7

Usage

Molecular weight

330.24 g/mol

Appearance

Pale yellow solid

Solubility

Slightly soluble in water, soluble in organic solvents like ethanol and methanol

Functional groups

Nitro group, phenyl group, methoxy group, carbonyl group, and pyrrolidinedione ring

Reactivity

Can undergo nucleophilic substitution, esterification, and other reactions due to the presence of functional groups

Structural versatility

Can be modified to create derivatives with specific properties

Utility

Used as a building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals, and as a valuable tool in the development of new molecules with potential therapeutic or industrial applications.

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 74124-79-1 di(succinimido) carbonate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 1228790-97-3 C₈₉H₉₀Cl₂N₁₂O₃₄ 
• 1224145-74-7 C₈₂H₈₅Cl₂N₁₁O₃₂ 
• 1228791-39-6 C₇₄H₈₀Cl₂N₁₀O₂₈ 
• 1154759-12-2 6'-(2-hydroxy-propanol)-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin 
• 1154758-53-8 6'-trifluoroacetyl-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin 
• 1154758-50-5 6'-trifluoroacetyl-2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-sisomicin 
• 1154758-40-3 2',3-diPNZ-1-(N-PNZ-4-amino-2(S)-hydroxy-butyryl)-3''-Boc-sisomicin 
• 1154758-46-9 6'-trifluoroacetyl-2',3-diPNZ-1-(N-Boc-3-amino-2(S)-hydroxy-propionyl)-3''-Boc-sisomicin 
• 1154758-43-6 6'-trifluoroacetyl-2',3-diPNZ-1-((R)-3-(tert-butoxycarbonylamino)-2-hydroxy-propionyl)-3''-Boc-sisomicin 
• 1154758-85-6 6'-(methyl-cyclopropyl)-2',3-diPNZ-1-(N-Boc-3-amino-2(R)-hydroxy-propionyl)-3''-Boc-sisomicin 
• 1154758-45-8 6'-trifluoroacetyl-2',3-diPNZ-1-(N-Boc-3-amino-2(S)-hydroxy-propionyl)-sisomicin 
• 1154758-42-5 6'-trifluoroacetyl-2',3-diPNZ-1-((R)-3-(tert-butoxycarbonylamino)-2-hydroxy-propionyl)-sisomicin 
• 1154758-44-7 2',3-diPNZ-1-((R)-3-(tert-butoxycarbonylamino)-2-hydroxy-propionyl)-3''-Boc-sisomicin 
• 1154758-33-4 6'-trifluoroacetyl-2',3-diPNZ-1-acetyl-3''-Boc-sisomicin 

Relevant academic research and scientific papers

Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry

Optimization of small-molecule probes or drugs is a synthetically lengthy, challenging, and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we demonstr

ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS

A method for treating a urinary tract infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.

ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS

Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R8 and R9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Acylation of amino acids

N-mono-substituted derivatives of diamino acids are prepared by the reaction of succinimidyl esters of carboxylic acids or substituted carbonic acids with the unprotected diamino acid. The acylation preferentially occurs at the side chain or terminal amino group of the diamino acid. For example, selective acylation of the terminal amino group of lysine occurs without first having protected the 2-amino group. Such acylation has application in the preparation of inter alia N6 -palmitoyl-lysine.