N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

Base Information

Chemical Name:N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide
CAS No.:195727-68-5
Molecular Formula:C₂₅H₃₆F₂N₄O₆
Molecular Weight:526.581
Hs Code.:

Synonyms:N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

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Chemical Property of N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

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Technology Process of N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

There total 3 articles about N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 195727-67-4
4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

: (S)-1-((S)-3-Methyl-2-phenoxycarbonylamino-butyryl)-pyrrolidine-2-carboxylic acid

: 195727-68-5
N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; for 24h;
DOI:10.1021/jm970250z

Reference yield:

: 195727-65-2
4(S)-[(benzyloxycarbonyl)amino]-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

: 195727-68-5
N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr

2: 83 percent / HOBT, N-methylmorpholine, EDC / tetrahydrofuran / 24 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm970250z

Reference yield:

: ethyl 4(S)-[(benzyloxycarbonyl)amino]-2,2-difluoro-3(R)-hydroxy-5-methylhexanoate

: 195727-68-5
N-[(phenoxycarbonyl)-L-valyl-L-prolyl]-4(S)-amino-2,2-difluoro-3(R)-hydroxy-N,5-dimethylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / ethanol; H₂O / 5 h

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 4 h / 2585.7 Torr

3: 83 percent / HOBT, N-methylmorpholine, EDC / tetrahydrofuran / 24 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm970250z