3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

Base Information

Chemical Name:3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate
CAS No.:1036712-85-2
Molecular Formula:C₃₃H₃₈FN₇O₅
Molecular Weight:631.707
Hs Code.:

Synonyms:3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

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Chemical Property of 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

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Technology Process of 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

There total 6 articles about 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1036712-84-1
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl] D-valinate

: 1036712-85-2
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 725685-92-7
3-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid ethyl ester

: 1036712-85-2
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrahydrofuran / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: sodium tetrahydroborate / ethanol / 20 °C

4: potassium carbonate / tetrahydrofuran

5: piperidine / N,N-dimethyl-formamide / 0.33 h / 20 °C

With piperidine; sodium tetrahydroborate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1036712-85-2
3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl D-valinate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 18 h / 90 °C

2: potassium carbonate / tetrahydrofuran / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

4: sodium tetrahydroborate / ethanol / 20 °C

5: potassium carbonate / tetrahydrofuran

6: piperidine / N,N-dimethyl-formamide / 0.33 h / 20 °C

With piperidine; sodium tetrahydroborate; sulfuric acid; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;