2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

Base Information

Chemical Name:2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide
CAS No.:74792-38-4
Molecular Formula:C₂₄H₄₀ClN₃O
Molecular Weight:422.054
Hs Code.:

Synonyms:2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

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Chemical Property of 2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

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Technology Process of 2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

There total 5 articles about 2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 74789-06-3
2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanenitrile

: 74792-38-4
2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

Guidance literature:: With sulfuric acid; for 2h; Heating;
DOI:10.1021/jm00184a008

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 74792-38-4
2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaNH₂ / toluene / 0.5 h / 80 - 85 °C

2: NaNH₂ / 1.) toluene, 100 deg C, 10 min, 2.) toluene, reflux, 45 min

3: 72 percent / 90percent aq. H₂SO₄ / 2 h / Heating

With sulfuric acid; sodium amide; In toluene;
DOI:10.1021/jm00184a008

Reference yield:

: 96-79-7
(2-chloroethyl)-diisopropylamine

: 74792-38-4
2-(2-Chloro-phenyl)-2-(2-diisopropylamino-ethyl)-5-piperidin-1-yl-pentanoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaNH₂ / toluene / 0.5 h / 80 - 85 °C

2: NaNH₂ / 1.) toluene, 100 deg C, 10 min, 2.) toluene, reflux, 45 min

3: 72 percent / 90percent aq. H₂SO₄ / 2 h / Heating

With sulfuric acid; sodium amide; In toluene;
DOI:10.1021/jm00184a008