(R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester

Base Information

• Chemical Name: (R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester
• CAS No.: 499775-31-4
• Molecular Formula: C₃₇H₄₅N₃O₉
• Molecular Weight: 675.779
• Mol file: 499775-31-4.mol

Synonyms:(R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester

Chemical Property of (R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester

There total 1 articles about (R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid (55878-47-2) + D-aspartic acid dibenzyl ester TFA salt → (R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester (499775-31-4)

Guidance literature:

With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In acetonitrile; for 18h;

DOI:10.1016/S0040-4020(02)01021-9

Reference yield:

(R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester (499775-31-4) → [(2R,5R)-5-(4-Benzyloxycarbonylamino-butyl)-3,6-dioxo-piperazin-2-yl]-acetic acid benzyl ester (499775-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 2 h / 20 °C

2: N-methylmorpholine; acetic acid / butan-2-ol / Heating

With 4-methyl-morpholine; acetic acid; In iso-butanol;

DOI:10.1016/S0040-4020(02)01021-9

Reference yield:

trifluoroacetic acid (76-05-1) + (R)-2-((R)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester (499775-31-4) → (R)-2-((R)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-succinic acid dibenzyl ester; compound with trifluoro-acetic acid

Guidance literature:

With acetic acid; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(02)01021-9

upstream raw materials:

(R)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoic acid

Downstream raw materials:

[(2R,5R)-5-(4-Benzyloxycarbonylamino-butyl)-3,6-dioxo-piperazin-2-yl]-acetic acid benzyl ester