Technology Process of 1-benzyl-3-cyclopropyl-1H-indazol-4-amine
There total 5 articles about 1-benzyl-3-cyclopropyl-1H-indazol-4-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzyl-3-cyclopropyl-4-nitro-1H-indazole;
With
iron; ammonium chloride;
In
ethanol; water;
at 85 ℃;
for 1h;
With
triethylamine;
In
ethyl acetate;
at 60 ℃;
for 0.166667h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2.1: bromine; acetic acid / 2 h / 80 °C / Sealed vial
2.2: pH 8
3.1: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 24 h / 100 °C / Inert atmosphere; Sealed vial
4.1: iron; ammonium chloride / ethanol; water / 1 h / 85 °C
4.2: 0.17 h / 60 °C
With
potassium phosphate; bromine; iron; potassium carbonate; ammonium chloride; acetic acid;
palladium diacetate; tricyclohexylphosphine;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2.1: bromine; acetic acid / 2 h / 80 °C / Sealed vial
2.2: pH 8
3.1: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 24 h / 100 °C / Inert atmosphere; Sealed vial
4.1: iron; ammonium chloride / ethanol; water / 1 h / 85 °C
4.2: 0.17 h / 60 °C
With
potassium phosphate; bromine; iron; potassium carbonate; ammonium chloride; acetic acid;
palladium diacetate; tricyclohexylphosphine;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
