2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole

Base Information

• Chemical Name: 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole
• CAS No.: 867019-38-3
• Molecular Formula: C₂₂H₂₁NO₂
• Molecular Weight: 331.414
• Mol file: 867019-38-3.mol

Synonyms:2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole

Chemical Property of 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole

There total 4 articles about 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(1',4'-dimethoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole (78265-15-3) + phenylmagnesium bromide → 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole (867019-38-3)

Guidance literature:

In diethyl ether; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2004.01.034

Reference yield:

1,4-dimethoxynaphthalene-2-carboxylic acid methyl ester (127536-35-0) → 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole (867019-38-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 10.80 g / NaOH / H₂O / 3 h / Heating

2: oxalyl chloride / CH₂Cl₂ / 24 h / 20 °C

3: Et₃N / 1,2-dichloro-ethane / 20 °C

4: 1.027 g / SOCl₂ / CH₂Cl₂; benzene / 4 h / 20 °C

5: 75 percent / diethyl ether / 24 h / 20 °C

With sodium hydroxide; thionyl chloride; oxalyl dichloride; triethylamine; In diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; benzene;

DOI:10.1016/j.tet.2004.01.034

Reference yield:

1,4-dimethoxynaphthalene-2-carboxylic acid (78265-13-1) → 2-(1'-phenyl-4'-methoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole (867019-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl chloride / CH₂Cl₂ / 24 h / 20 °C

2: Et₃N / 1,2-dichloro-ethane / 20 °C

3: 1.027 g / SOCl₂ / CH₂Cl₂; benzene / 4 h / 20 °C

4: 75 percent / diethyl ether / 24 h / 20 °C

With thionyl chloride; oxalyl dichloride; triethylamine; In diethyl ether; dichloromethane; 1,2-dichloro-ethane; benzene;

DOI:10.1016/j.tet.2004.01.034

upstream raw materials:

2-(1',4'-dimethoxynaphth-2'-yl)-4,4-dimethyl-4,5-dihydrooxazole

1,4-dimethoxynaphthalene-2-carboxylic acid methyl ester

1,4-dimethoxy-2-naphthoyl chloride

1,4-dimethoxynaphthalene-2-carboxylic acid

Downstream raw materials:

4-Methoxy-1-phenyl-2-naphthoic acid