DIMETHYL 5-(3,4-DICHLOROPHENYL)-1H-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE

Base Information

• Chemical Name: DIMETHYL 5-(3,4-DICHLOROPHENYL)-1H-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE
• CAS No.: 110271-25-5
• Molecular Formula: C₁₆H₁₃Cl₂NO₄S
• Molecular Weight: 386.256
• Mol file: 110271-25-5.mol

Synonyms:dimethyl 5-(3,3-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate

Chemical Property of DIMETHYL 5-(3,4-DICHLOROPHENYL)-1H-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Dimethyl 5-(3,4-dichlorophenyl)-1H-pyrrolo[1,2-c][1,3]thiazole-6,7-dicarboxylate ^*data from reagent suppliers

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Technology Process of DIMETHYL 5-(3,4-DICHLOROPHENYL)-1H-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE

There total 2 articles about DIMETHYL 5-(3,4-DICHLOROPHENYL)-1H-PYRROLO[1,2-C][1,3]THIAZOLE-6,7-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

dimethyl acetylenedicarboxylate (762-42-5) + N-(3,4-dichlorobenzoyl)thiazolidine-4-carboxylic acid (110271-24-4) → dimethyl 5-(3,3-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate (110271-25-5)

Guidance literature:

With acetic anhydride; at 120 ℃; for 6h;

DOI:10.1021/jm00394a030

Reference yield:

3,4-dichlorobenzoyl chloride (3024-72-4) → dimethyl 5-(3,3-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate (110271-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / aq. 15percent NaOH / H₂O; diethyl ether / 16 h / 25 °C

2: 68 percent / acetic anhydride / 6 h / 120 °C

With sodium hydroxide; acetic anhydride; In diethyl ether; water;

DOI:10.1021/jm00394a030

Reference yield: 76.0%

dimethyl 5-(3,3-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate (110271-25-5) → dimethyl 2,2-dioxo-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate (107124-27-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jm00394a030

upstream raw materials:

dimethyl acetylenedicarboxylate

N-(3,4-dichlorobenzoyl)thiazolidine-4-carboxylic acid

3,4-dichlorobenzoyl chloride

Downstream raw materials:

6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole

dimethyl 2,2-dioxo-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole-6,7-dicarboxylate

6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

2-oxo-6,7-bis(hydroxymethyl)-5-(3,4-dichlorophenyl)-1,3-dihydropyrrolo<1,2-c>thiazole bis

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