ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Base Information

Chemical Name:ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate
CAS No.:197223-27-1
Molecular Formula:C₃₅H₄₁N₅O₈S
Molecular Weight:691.805
Hs Code.:

ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Synonyms:ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

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Chemical Property of ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

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Technology Process of ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

There total 5 articles about ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 138899-84-0
4--N-prop-2-ynylamino>benzoic acid, trifluoroacetate salt

: 197223-22-6
ethyl (2S)-2-[(4S)-4-amino-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

: 197223-27-1
ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2.2h;
DOI:10.1016/S0040-4020(97)00851-X

Reference yield:

: 5672-83-3
Z-L-GluOMe

: 197223-27-1
ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -20 °C

2: 2.75 g / N-methylmorpholine / tetrahydrofuran / 1.67 h / -20 - 20 °C

3: 90 percent / Lawesson's reagent / tetrahydrofuran / 20 °C / Heating

4: 62 percent / hydrogen bromide / acetic acid / 0.33 h / 20 °C

5: 44 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 2.2 h / 0 - 20 °C

With Lawessons reagent; 4-methyl-morpholine; diethyl cyanophosphonate; hydrogen bromide; triethylamine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation / 3: thionation / 4: acidolysis / 5: Condensation;
DOI:10.1016/S0040-4020(97)00851-X

Reference yield:

: 15149-59-4
diethyl N-[α-methyl N-(benzyloxycarbonyl)-L-γ-glutamyl]-L-glutamate

: 197223-27-1
ethyl (2S)-2-[(4S)-4-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]benzamido]-4-(methoxycarbonyl)butanethioamido]-4-(ethoxycarbonyl)butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Lawesson's reagent / tetrahydrofuran / 20 °C / Heating

2: 62 percent / hydrogen bromide / acetic acid / 0.33 h / 20 °C

3: 44 percent / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 2.2 h / 0 - 20 °C

With Lawessons reagent; diethyl cyanophosphonate; hydrogen bromide; triethylamine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; 1: thionation / 2: acidolysis / 3: Condensation;
DOI:10.1016/S0040-4020(97)00851-X