4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester

Base Information

• Chemical Name: 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester
• CAS No.: 396124-23-5
• Molecular Formula: C₂₂H₂₁N₇O₃
• Molecular Weight: 431.454

Synonyms:4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester

Chemical Property of 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester

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Technology Process of 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester

There total 2 articles about 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

ethyl 4-(3-chloropropyl)benzoate (86911-10-6) + 2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine (162401-16-3,321661-12-5) → 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester (396124-23-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/jm010924c

Reference yield:

4-(3-Hydroxypropyl)benzonitrile (83101-12-6) → 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester (396124-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / H₂SO₄ / 24 h / Heating

2: 91 percent / SOCl₂; pyridine / benzene / 2 h / 20 °C

3: 56 percent / K₂CO₃ / dimethylformamide / 100 °C

With pyridine; thionyl chloride; sulfuric acid; potassium carbonate; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm010924c

Reference yield: 97.0%

4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester (396124-23-5) → 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid

Guidance literature:

With aq. 10percent NaOH; for 0.5h; Heating;

DOI:10.1021/jm010924c

upstream raw materials:

ethyl 4-(3-chloropropyl)benzoate

2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine

4-(3-Hydroxypropyl)benzonitrile

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