Technology Process of (2R,3R)-3-methoxy-5-(4-methoxyphenyl)-2-methyl-(4E)-penten-1-ol
There total 17 articles about (2R,3R)-3-methoxy-5-(4-methoxyphenyl)-2-methyl-(4E)-penten-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
for 0.5h;
Ambient temperature;
DOI:10.1248/cpb.43.1111
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 42 percent / Zn / benzene / 1 h / Heating
2: 92 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / diethyl ether / 0.5 h / Ambient temperature
3: 14 percent / Zn(BH4)2 / diethyl ether / 0 °C
4: 96 percent / LiBH4 / tetrahydrofuran / 0.5 h / Ambient temperature
5: diisopropyl ether / 2 h / 33 °C / immobilized lipase "Amano P"
6: 89 percent / K2CO3 / methanol; H2O / 2 h / Ambient temperature
7: imidazole / dimethylformamide / 2 h / 0 °C
8: KH / tetrahydrofuran / 3 h / Ambient temperature
9: tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature
With
1H-imidazole; lithium borohydride; zinc(II) tetrahydroborate; tetrabutyl ammonium fluoride; potassium hydride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc;
In
tetrahydrofuran; methanol; diethyl ether; di-isopropyl ether; water; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.43.1111
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 2 percent / Zn(BH4)2 / diethyl ether / 0 °C
2: 96 percent / LiBH4 / tetrahydrofuran / 0.25 h / Ambient temperature
3: 85 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / diethyl ether / 0.25 h / Ambient temperature
4: Zn(BH4)2 / diethyl ether / 1 h / 0 °C
5: diisopropyl ether / 2 h / 33 °C / immobilized lipase "Amano P"
6: 89 percent / K2CO3 / methanol; H2O / 2 h / Ambient temperature
7: imidazole / dimethylformamide / 2 h / 0 °C
8: KH / tetrahydrofuran / 3 h / Ambient temperature
9: tetrabutylammonium fluoride / tetrahydrofuran / 4 h / Ambient temperature
With
1H-imidazole; lithium borohydride; zinc(II) tetrahydroborate; tetrabutyl ammonium fluoride; potassium hydride; potassium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; di-isopropyl ether; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.1111
