[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester
CAS No.:165808-21-9
Molecular Formula:C₂₇H₂₈N₂O₅S₃
Molecular Weight:556.728
Hs Code.:

[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2<i>H</i>-thieno[2,3-<i>d</i>]pyrimidin-3-yl]-acetic acid ethyl ester

Synonyms:[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

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Chemical Property of [5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

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Technology Process of [5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

There total 9 articles about [5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 165808-21-9
[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NH₄OAc, AcOH / benzene / 24 h / Heating

2: S, Et₂NH / ethanol / 2 h / 60 °C

3: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

4: 85 percent / AlCl₃, dimethyl disulfide / CH₂Cl₂ / 20 h / Ambient temperature

5: pyridine / 3 h / Ambient temperature

6: K₂CO₃ / dimethylformamide / 13 h / Ambient temperature

7: 78 percent / aq. K₂CO₃ / methanol; tetrahydrofuran / 0.67 h / Ambient temperature

8: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

With pyridine; aluminium trichloride; Dimethyldisulphide; ammonium acetate; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; diethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.46.1724

Reference yield:

: 26190-68-1
1-chloromethyl-2-methylsulfanylbenzene

: 165808-21-9
[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 13 h / Ambient temperature

2: 78 percent / aq. K₂CO₃ / methanol; tetrahydrofuran / 0.67 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

With sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1724

Reference yield:

: 165809-38-1
2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester

: 165808-21-9
[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-methylsulfanylmethoxy-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

2: 85 percent / AlCl₃, dimethyl disulfide / CH₂Cl₂ / 20 h / Ambient temperature

3: pyridine / 3 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / 13 h / Ambient temperature

5: 78 percent / aq. K₂CO₃ / methanol; tetrahydrofuran / 0.67 h / Ambient temperature

6: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h

With pyridine; aluminium trichloride; Dimethyldisulphide; sodium ethanolate; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1724