methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

Base Information

Chemical Name:methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate
CAS No.:1357191-96-8
Molecular Formula:C₂₃H₂₁F₂N₃O₅
Molecular Weight:457.434
Hs Code.:

Synonyms:methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

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Chemical Property of methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

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Technology Process of methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

There total 6 articles about methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1357191-96-8
methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

3.1: trifluoroacetic acid / tetrahydrofuran / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: acetic acid; zinc / tetrahydrofuran / 0.25 h / 0 °C

6.1: sodium nitrite; hydrogenchloride / water / 0.25 h / 0 °C

6.2: 0.25 h / 0 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; zinc; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 1357191-95-7
2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)aniline

: 1357191-96-8
methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

Guidance literature:: 2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.25h;

4-methoxyacetoacetic acid methylester; With sodium acetate; In methanol; water; at 0 ℃; for 0.25h;

Reference yield:

: 1187386-34-0
4-bromo-2-(tert-butoxy)-1-nitrobenzene

: 1357191-96-8
methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / tetrahydrofuran / 3 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: acetic acid; zinc / tetrahydrofuran / 0.25 h / 0 °C

5.1: sodium nitrite; hydrogenchloride / water / 0.25 h / 0 °C

5.2: 0.25 h / 0 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium t-butanolate; zinc; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;