4-Bromo-2-t-butoxy-1-nitrobenzene

Base Information

• Chemical Name: 4-Bromo-2-t-butoxy-1-nitrobenzene
• CAS No.: 1187386-34-0
• Molecular Formula: C10H12BrNO3
• Molecular Weight: 274.114
• Hs Code.: 2909309090
• Mol file: 1187386-34-0.mol

Synonyms:4-Bromo-2-t-butoxy-1-nitrobenzene;4-Bromo-2-tert-butoxy-1-nitrobenzene;2-tert-butoxy-4-bromo-1-nitrobenzene

Chemical Property of 4-Bromo-2-t-butoxy-1-nitrobenzene

Chemical Property:

• PSA: 55.05000
• LogP: 4.05780
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-t-butoxy-1-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-t-butoxy-1-nitrobenzene

There total 4 articles about 4-Bromo-2-t-butoxy-1-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-bromo-2-methoxy-1-nitro-benzene (103966-66-1) + sodium t-butanolate (865-48-5) → 4-bromo-2-(tert-butoxy)-1-nitrobenzene (1187386-34-0)

Guidance literature:

In 1,2-dimethoxyethane; toluene; at 110 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1371/journal.pone.0183575

Reference yield: 16.0%

4-bromo-2-methoxy-1-nitro-benzene (103966-66-1) + tert-butyl alcohol (75-65-0) → 4-bromo-2-(tert-butoxy)-1-nitrobenzene (1187386-34-0)

Guidance literature:

tert-butyl alcohol; With potassium tert-butylate; at 90 ℃; Inert atmosphere;

4-bromo-2-methoxy-1-nitro-benzene; With 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.201901779

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) + potassium tert-butylate (865-47-4) → 4-bromo-2-(tert-butoxy)-1-nitrobenzene (1187386-34-0)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.5h;

upstream raw materials:

4-bromo-2-fluoronitrobenzene

potassium tert-butylate

4-bromo-2-methoxy-1-nitro-benzene

sodium t-butanolate

Downstream raw materials:

1-[3-(benzyloxy)-4-nitrophenyl]-3,4-difluoro-1H-pyrrole

2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)aniline

methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate

methyl 1-[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]-5-methoxy-4-oxo-1,4-dihydropyridazine-3-carboxylate

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