N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Base Information

• Chemical Name: N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide
• CAS No.: 1198620-29-9
• Molecular Formula: C₂₉H₂₆FN₃O₅
• Molecular Weight: 515.541

Synonyms:N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Chemical Property of N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Chemical Property:

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Technology Process of N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

There total 5 articles about N₂,3-bis(benzyloxy)-N₅-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,7-bis(benzyloxy)-3-oxo-1,3-dihydrofuro[3,4-c]pyridine-6-carboxamide (1198621-05-4) + para-fluorobenzylamine (140-75-0) → N2,3-bis(benzyloxy)-N5-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide (1198620-29-9)

Guidance literature:

at 70 ℃; for 0.5h;

Reference yield:

N,3-bis(benzyloxy)-4,5-bis(hydroxymethyl)picolinamide (1198621-04-3) → N2,3-bis(benzyloxy)-N5-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide (1198620-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 20 °C

2: 0.5 h / 70 °C

With manganese(IV) oxide; In dichloromethane;

Reference yield:

N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide (1198621-03-2) → N2,3-bis(benzyloxy)-N5-(4-fluorobenzyl)-4-(hydroxymethyl)pyridine-2,5-dicarboxamide (1198620-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid / tetrahydrofuran; water / 2 h / 70 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: 0.5 h / 70 °C

With manganese(IV) oxide; formic acid; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

N,7-bis(benzyloxy)-3-oxo-1,3-dihydrofuro[3,4-c]pyridine-6-carboxamide

para-fluorobenzylamine

N,3-bis(benzyloxy)-4,5-bis(hydroxymethyl)picolinamide

N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

Downstream raw materials:

N₅-(4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

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