N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

Base Information

Chemical Name:N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide
CAS No.:1198621-03-2
Molecular Formula:C₂₅H₂₆N₂O₅
Molecular Weight:434.492
Hs Code.:

Synonyms:N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

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Chemical Property of N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

Chemical Property:

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Technology Process of N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

There total 1 articles about N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 62489-21-8
9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester

: 1198621-03-2
N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

Guidance literature:: O-benzylhydoxylamine hydrochloride; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

: 1198621-03-2
N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

: 1198621-04-3
N,3-bis(benzyloxy)-4,5-bis(hydroxymethyl)picolinamide

Guidance literature:: N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide; With formic acid; In tetrahydrofuran; water; at 70 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 1198621-03-2
N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide

: N₅-(3-chloro-4-fluorobenzyl)-N₂,3-dihydroxy-4-(hydroxymethyl)pyridine-2,5-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: formic acid / tetrahydrofuran; water / 2 h / 70 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: N,N-dimethyl-formamide / 2 h / 90 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With manganese(IV) oxide; formic acid; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;