2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

Base Information

Chemical Name:2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone
CAS No.:273200-81-0
Molecular Formula:C₁₁H₇BrO₃
Molecular Weight:267.079
Hs Code.:
DSSTox Substance ID:DTXSID901244189
Nikkaji Number:J1.288.888K

Synonyms:2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone;SCHEMBL20364889;DTXSID901244189;273200-81-0;2-Bromo-5-hydroxy-7-methyl-1,4-naphthalenedione

Suppliers and Price of 2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:265.95786
Heavy Atom Count:15
Complexity:348

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C(=C1)O)C(=O)C=C(C2=O)Br

Technology Process of 2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

There total 6 articles about 2-Bromo-5-hydroxy-7-methyl-1,4-naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14787-38-3
7-methyljuglone

: 161811-59-2
2-bromo-8-hydroxy-6-methyl-1,4-naphthoquinone

: 273200-81-0
2-bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

Guidance literature:: With bromine; In acetic acid; at 20 ℃; for 0.416667h; Darkness; Inert atmosphere;
DOI:10.1021/acs.jnatprod.0c00800

Reference yield:

: 101459-25-0
2-bromo-5,8-dimethoxy-3-methylnaphthalen-1-ol

: 161811-59-2
2-bromo-8-hydroxy-6-methyl-1,4-naphthoquinone

: 273200-81-0
2-bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.17 h / -35 - -20 °C / Inert atmosphere

1.2: -35 - -20 °C / Inert atmosphere

1.3: -20 °C / Acidic conditions; Inert atmosphere

2.1: pyridine hydrochloride / 0.5 h / Reflux

2.2: 0.67 h / 20 °C

3.1: bromine / acetic acid / 0.42 h / 20 °C / Darkness; Inert atmosphere

With n-butyllithium; bromine; pyridine hydrochloride; In tetrahydrofuran; acetic acid;
DOI:10.1021/acs.jnatprod.0c00800

Reference yield:

: 50559-08-5
5,8-dimethoxy-3-methylnaphthalen-1-ol

: 161811-59-2
2-bromo-8-hydroxy-6-methyl-1,4-naphthoquinone

: 273200-81-0
2-bromo-5-hydroxy-7-methyl-1,4-naphthoquinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine hydrochloride / 0.5 h / Reflux

1.2: 0.67 h / 20 °C

2.1: bromine / acetic acid / 0.42 h / 20 °C / Darkness; Inert atmosphere

With bromine; pyridine hydrochloride; In acetic acid;
DOI:10.1021/acs.jnatprod.0c00800