3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

Base Information

Chemical Name:3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate
CAS No.:1332755-75-5
Molecular Formula:C₄₆H₄₇F₂NO₇
Molecular Weight:763.878
Hs Code.:

Synonyms:3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

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Chemical Property of 3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

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Technology Process of 3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

There total 18 articles about 3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 4-((4'-hydroxybiphenyl-3-yloxy)carbonyl)phenyl-2,3-difluoro-4-(tetradecyloxy)benzoate

: 39178-35-3
isonicotinoyl chloride hydrochloride

: 1332755-75-5
3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ja205550b

Reference yield:

: 1332755-86-8
4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate

: 1332755-75-5
3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

2: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

4: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja205550b

Reference yield:

: 591-20-8
3-Bromophenol

: 1332755-75-5
3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 5 h / 80 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

5: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/ja205550b