4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate

Base Information

• Chemical Name: 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate
• CAS No.: 1332755-86-8
• Molecular Formula: C₃₅H₄₂F₂O₅
• Molecular Weight: 580.712
• Mol file: 1332755-86-8.mol

Synonyms:4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate

Chemical Property of 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate

There total 7 articles about 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Benzyl 4-hydroxybenzoate (94-18-8) + 4-tetradecyloxy-2,3-difluorobenzoic acid → 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate (1332755-86-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja205550b

Reference yield:

ortho-difluorobenzene (367-11-3) → 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate (1332755-86-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: trialkyl borate / -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: dihydrogen peroxide / diethyl ether; water / Reflux

3.1: potassium carbonate; potassium iodide / acetone / 48 h / Reflux

4.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With dmap; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; dihydrogen peroxide; potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; In tetrahydrofuran; diethyl ether; hexane; water; acetone;

DOI:10.1021/ja205550b

Reference yield:

2,3-difluorophenol (6418-38-8) → 4-(benzyloxycarbonyl)phenyl 4-tetradecyloxy-2,3-difluorobenzoate (1332755-86-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / acetone / 48 h / Reflux

2.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With dmap; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; In tetrahydrofuran; acetone;

DOI:10.1021/ja205550b

upstream raw materials:

ortho-difluorobenzene

2,3-difluorophenol

Benzyl 4-hydroxybenzoate

(2,3-difluorophenyl)boronic acid

Downstream raw materials:

3'-(4-(2,3-difluoro-4-(tetradecyloxy)benzoyloxy)benzoyloxy)biphenyl-4-yl isonicotinate

C₆₅H₇₂F₂O₁₀

C₇₂H₉₄F₂O₁₂Si₃

C₇₁H₈₄F₂O₁₂