2-(P-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER

Base Information

• Chemical Name: 2-(P-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER
• CAS No.: 19056-84-9
• Molecular Formula: C15H19 N O4
• Molecular Weight: 277.32
• Hs Code.: 2922499990
• Mol file: 19056-84-9.mol

Synonyms:Malonicacid, (p-toluidinomethylene)-, diethyl ester (8CI); Propanedioic acid, [[(4-methylphenyl)amino]methylene]-,diethyl ester (9CI)

Chemical Property of 2-(P-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER

Chemical Property:

• Vapor Pressure: 4.37E-05mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 165.8°C
• PSA: 64.63000
• Density: 1.15g/cm³
• LogP: 2.49000

Purity/Quality:

98%min ^*data from raw suppliers

DIETHYL 2-(4-TOLUIDINOMETHYLENE)MALONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(P-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER

There total 10 articles about 2-(P-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-toluidine (106-49-0,12221-03-3) + diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl 2-[(p-tolylamino)methylidene]malonate (19056-84-9)

Guidance literature:

In neat (no solvent); at 120 ℃; for 0.75h;

DOI:10.1021/acs.cgd.0c01010

Reference yield: 94.0%

diethyl 2-ethoxymethylenemalonate (87-13-8) + 4-bromo-aniline (106-40-1) → diethyl 2-[(p-tolylamino)methylidene]malonate (19056-84-9)

Guidance literature:

diethyl 2-ethoxymethylenemalonate; 4-bromo-aniline; at 20 ℃;

at 100 ℃; for 2.5h;

DOI:10.1021/acs.jmedchem.5b00515

Reference yield: 81.3%

→ diethyl 2-[(p-tolylamino)methylidene]malonate (19056-84-9)

Guidance literature:

In toluene; for 6h; Reflux;

upstream raw materials:

p-toluidine

diethyl 2-ethoxymethylenemalonate

Diazoethan

2-(p-tolylamino-methylene)-malonic acid monoethyl ester

Downstream raw materials:

ethyl 6-bromo-4-oxo-1,4-dihydro-quinoline-3-carboxylate

6-bromo-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

6-bromo-3-quinolinecarboxylic acid-4-ol

6-bromo-4-chloroquinoline