Technology Process of C32H44N4O10
There total 10 articles about C32H44N4O10 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-L-phenylalanine;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
C12H17NO5;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/ol5002126
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide / water; tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
2.2: 8 h / 0 - 20 °C / Inert atmosphere
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol5002126
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Inert atmosphere; Reflux
2.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 65 °C / Inert atmosphere
3.1: hydrogen; palladium on activated charcoal / ethyl acetate / 1 h / 760.05 Torr
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
4.2: 8 h / 0 - 20 °C / Inert atmosphere
With
N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol5002126
