N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine

Base Information

• Chemical Name: N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine
• CAS No.: 90013-38-0
• Molecular Formula: C₂₅H₃₁N₅O₇
• Molecular Weight: 513.55
• Mol file: 90013-38-0.mol

Synonyms:N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine

Chemical Property of N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine

There total 6 articles about N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N1-benzyloxycarbonylglycylglycinamidoethyl-N2-tert-butoxycarbonyl-O4-benzylhydrogen-L-isoasparagine (90013-37-9) → N1-benzyloxycarbonylglycylglycinamidoethyl-O4-benzylhydrogen-L-isoasparagine (90013-38-0)

Guidance literature:

In trifluoroacetic acid; Ambient temperature;

DOI:10.1002/jps.2600730237

Reference yield:

CbzGlyGly (2566-19-0) → N1-benzyloxycarbonylglycylglycinamidoethyl-O4-benzylhydrogen-L-isoasparagine (90013-38-0)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 4 °C

2: base, pH 8.5 / H₂O / Ambient temperature

3: Et₃N / H₂O; dimethylformamide / 12 h / Ambient temperature

4: 67 percent / trifluoroacetic acid / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In water; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1002/jps.2600730237

Reference yield:

Cbz-Gly-Gly-OSucc (32943-08-1) → N1-benzyloxycarbonylglycylglycinamidoethyl-O4-benzylhydrogen-L-isoasparagine (90013-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1: base, pH 8.5 / H₂O / Ambient temperature

2: Et₃N / H₂O; dimethylformamide / 12 h / Ambient temperature

3: 67 percent / trifluoroacetic acid / Ambient temperature

With triethylamine; In water; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1002/jps.2600730237

upstream raw materials:

N¹-benzyloxycarbonylglycylglycinamidoethyl-N²-tert-butoxycarbonyl-O⁴-benzylhydrogen-L-isoasparagine

Cbz-Gly-Gly-OSucc

CbzGlyGly

BOC-L-aspartic acid 4-benzyl ester

Downstream raw materials:

(S)-N-{2-[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-ethyl}-3-(2-phosphono-acetylamino)-succinamic acid benzyl ester