32943-08-1

Usage

Uses

Used in Drug Discovery:
Z-GLY-GLY-OSU is used as a protective group for amino acids to allow for selective modification of peptide sequences, which is crucial for the development of new drugs with specific therapeutic properties.
Used in Chemical Biology:
Z-GLY-GLY-OSU is used as a chemical handle for the attachment of other molecules or functional groups, enabling the creation of complex peptide structures that can be used to study biological processes and interactions.
Used in Biotechnology Applications:
Z-GLY-GLY-OSU is used to create complex peptide structures for various biotechnological applications, such as the development of biosensors, diagnostic tools, and therapeutic agents.
Used in Peptide Synthesis:
Z-GLY-GLY-OSU is used as a protective group in the synthesis of peptides, allowing for the precise control and manipulation of peptide sequences to achieve desired properties and functions.
Used in Bioconjugation:
Z-GLY-GLY-OSU is used as a chemical handle for the attachment of other molecules or functional groups to peptides, enabling the creation of bioconjugates for various applications, such as targeted drug delivery and imaging agents.

Upstream product

• 2566-19-0 CbzGlyGly 
• 2899-60-7 Cbz-Gly-ONSuc 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 

Downstream Products

• 68835-85-8 N-benzyloxycarbonyl-glycyl-glycyl-(S)phenylalanyl-(S)leucine methyl ester 
• 721388-77-8 1-N-(benzyloxycarbonylglycylglycyl)ethylenediamine 
• 13171-93-2 N-benzyloxycarbonyl-L-glycyl-L-glycyl-L-phenylalanine 
• 1213228-12-6 N-(N-benzyloxycarbonyldiglycyl)-N-[N-(β-D-galactopyranosyl)carbamoylmethyl]-N-{N,N-bis[N-(β-D-galactopyranosyl)carbamoylmethyl]carbamoylmethyl}amine 
• 86831-99-4 7-(Z-Glycylglycyl-L-arginamido)-3-phenylcoumarin 
• 90013-39-1 (S)-N-{2-[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-ethyl}-3-(2-phosphono-acetylamino)-succinamic acid benzyl ester 
• 90013-37-9 N¹-benzyloxycarbonylglycylglycinamidoethyl-N²-tert-butoxycarbonyl-O⁴-benzylhydrogen-L-isoasparagine 
• 90013-38-0 N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine 

Relevant academic research and scientific papers

Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: A strategy for the design of peptidase inhibitors

The cholecystokinin-8 (CCK-8)-inactivating peptidase is a serine peptidase which has been shown to be a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10). It cleaves the neurotransmitter CCK-8 sulfate at the Met-Gly bond to give Asp-Tyr(SO3H)-Met-OH + Gly-Trp-Met-Asp-Phe-NH2. In seeking a reversible inhibitor of this peptidase, the enzymatic binding subsites were characterized using a fluorimetric assay based on the hydrolysis of the artificial substrate Ala-Ala-Phe-amidomethylcoumarin. A series of di- and tripeptides having various alkyl or aryl side chains was studied to determine the accessible volume for binding and to probe the potential for hydrophobic interactions. From this initial study the tripeptides Ile-Pro-Ile-OH (K(i) = 1 μM) and Ala-Pro-Ala-OH (K(i) = 3 μM) and dipeptide amide Val-Nvl-NHBu (K(i) = 3 μM) emerged as leads. Comparison of these structures led to the synthesis of Val-Pro-NHBu (K(i) = 0.57 μM) which served for later optimization in the design of butabindide, a potent reversible competitive and selective inhibitor of the CCK-8-inactivating peptidase. The strategy for this work is explicitly described since it illustrates a possible general approach for peptidase inhibitor design.

Cytotoxic N,N'-bis (succinyl-peptide-) derivatives of 1,4-bis (aminoalkyl)-5,8-dihydroxyanthraquinones and antibody conjugates thereof

The present invention is concerned with novel N,N'-bis(succinyl-peptide)-derivatives of 1,4-bis(aminoalkyl)-5,8-dihydroxyanthraquinones and the corresponding antibody conjugates thereof each of which have potential use in the treatment of human carcinomas.

Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones

Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.

New compounds: Peptide derivatives of the antitumor agent N-phosphonoacetyl-L-aspartic acid

Two peptide forms of the antitumor transition state analogue N-phosphonoacetyl-L-aspartic acid (N2-phosphonoacetyl-N4-glycylglycinamidoethyl-L-asparagine and N1-glycylglycinamidoethyl-N2-phosphonoacetyl-L-isoasparagine) have been synthesized to obtain potential medicinal agents useful as prodrugs or in a lysosomotropic carrier approach. The bridging unit, ethylenediamine, used for synthetic purposes might be of general interest.