Technology Process of C23H27BN2O8
There total 4 articles about C23H27BN2O8 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-{4-[2-(3-tert-butoxycarbonyl-2-methoxy-phenyl)-1-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0(2,6)]dec-4-yl)-ethyl-carbamoyl]benzyl}piperidine-3-caroxylic acid ethyl ester;
With
boron trichloride;
In
dichloromethane;
at -78 - 0 ℃;
Inert atmosphere;
With
sodium hydroxide;
In
water;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 1,4-dioxane; water / 18 h / 0 - 20 °C / Sealed tube
2.1: tetrahydrofuran / 1 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / -100 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -100 °C / Inert atmosphere
4.2: -100 - 0 °C / Inert atmosphere
4.3: -78 - 20 °C / Inert atmosphere
5.1: dichloromethane / -20 - 20 °C / Inert atmosphere
6.1: sodium carbonate / acetonitrile / 1 h / 20 °C
7.1: boron trichloride / dichloromethane / -78 - 0 °C / Inert atmosphere
7.2: 2 h / 20 °C
With
n-butyllithium; boron trichloride; sodium carbonate;
sulfuric acid;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / -100 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -100 °C / Inert atmosphere
2.2: -100 - 0 °C / Inert atmosphere
2.3: -78 - 20 °C / Inert atmosphere
3.1: dichloromethane / -20 - 20 °C / Inert atmosphere
4.1: sodium carbonate / acetonitrile / 1 h / 20 °C
5.1: boron trichloride / dichloromethane / -78 - 0 °C / Inert atmosphere
5.2: 2 h / 20 °C
With
n-butyllithium; boron trichloride; sodium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;