(4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Base Information

Chemical Name:(4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone
CAS No.:1396778-41-8
Molecular Formula:C₂₅H₂₅N₇O
Molecular Weight:439.52
Hs Code.:

Synonyms:(4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Suppliers and Price of (4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

There total 8 articles about (4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1396779-92-2
(4-(3-amino-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

: 100-52-7
benzaldehyde

: 1396778-41-8
(4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1396778-41-8
(4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 14 h

2: potassium hydroxide / tBu₄NI / toluene / 4 h

3: potassium phosphate / L-proline; copper(l) iodide / dimethyl sulfoxide / 90 °C

4: triethylamine / dichloromethane / 1.25 h / 5 - 20 °C

5: tin(II) chloride hydrate / ethyl acetate / 20 °C

6: sodium azide / acetic acid / 4 h / 90 °C

7: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / methanol / Inert atmosphere

8: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; sodium azide; tin(II) chloride hydrate; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; copper(l) iodide; 5%-palladium/activated carbon; L-proline; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetic acid; dimethyl sulfoxide; ethyl acetate; toluene;

Reference yield:

: 1396779-88-6
(4-(4-amino-3-(dibenzylamino)phenyl)piperazin-1-yl)(phenyl)methanone

: 1396778-41-8
(4-(3-(benzylamino)-4-(1H-tetrazol-1-yl)phenyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / acetic acid / 4 h / 90 °C

2: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / methanol / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 5%-palladium/activated carbon; In methanol; dichloromethane; acetic acid;