N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

Base Information

Chemical Name:N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide
CAS No.:1187992-07-9
Molecular Formula:C₂₄H₂₂N₆O₄
Molecular Weight:458.476
Hs Code.:

Synonyms:N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

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Chemical Property of N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

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Technology Process of N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

There total 7 articles about N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187992-93-3
4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid

: 1187993-14-1
1-(2,4-dimethoxyphenyl)-1-(6-methylpyridin-2-yl)methanamine hydrochloride

: 1187992-07-9
N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

Guidance literature:: 4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

1-(2,4-dimethoxyphenyl)-1-(6-methylpyridin-2-yl)methanamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 - 70 ℃;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 1187163-23-0
(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methanone

: 1187992-07-9
N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 24 h / 60 °C

2.1: sodium tetrahydroborate / methanol / 0.75 h / 0 °C

2.3: 0.25 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 120 °C

3.2: 20 - 70 °C

3.3: pH 5

With titanium(IV) tetraethanolate; sodium tetrahydroborate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1187993-15-2
N-[(1Z)-(2,4-dimethoxyphenyl)(6-methylpyridin-2-yl)methylene]-2-methylpropane-2-sulfinamide

: 1187992-07-9
N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 0.75 h / 0 °C

1.3: 0.25 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 120 °C

2.2: 20 - 70 °C

2.3: pH 5

With sodium tetrahydroborate; 1,1'-carbonyldiimidazole; In methanol; N,N-dimethyl-formamide;