Technology Process of N-[7-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-methanesulfonamide
There total 7 articles about N-[7-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carbonyl]-methanesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methanesulfonamide;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 - 25 ℃;
for 1h;
7-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / 12 h / 0 °C / Reflux
2.1: toluene-4-sulfonic acid / toluene / 12 h / Reflux
3.1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C
4.1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
5.1: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 - 25 °C
7.2: 1 h / 25 °C
With
triethylsilane; thionyl chloride; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide;
copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
3.1: Diels-Alder Reaction / 5.1: Ullmann Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
2.1: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 - 25 °C
4.2: 1 h / 25 °C
With
triethylsilane; water; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium hydroxide;
copper(l) iodide; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
2.1: Ullmann Reaction;
