Technology Process of 7-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid
There total 5 articles about 7-fluoro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 12 h / 0 °C / Reflux
2: toluene-4-sulfonic acid / toluene / 12 h / Reflux
3: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 16 h / 25 °C
4: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
5: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
6: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
With
triethylsilane; thionyl chloride; water; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide;
copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;
3: Diels-Alder Reaction / 5: Ullmann Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic acid; triethylsilane / 3 h / 25 °C
2: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
3: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
With
triethylsilane; water; potassium carbonate; trifluoroacetic acid; sodium hydroxide;
copper(l) iodide; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
2: Ullmann Reaction;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C
2: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 70 °C
With
water; potassium carbonate; sodium hydroxide;
copper(l) iodide; N,N-dimethylglycine hydrochoride;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
1: Ullmann Reaction;