1H-Benzimidazole,3-oxide(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,3-oxide(9CI)
• CAS No.: 18916-43-3
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.137
• Mol file: 18916-43-3.mol

Synonyms:Benzimidazole,3-oxide (6CI,7CI,8CI)

Chemical Property of 1H-Benzimidazole,3-oxide(9CI)

Chemical Property:

• PSA: 41.25000
• LogP: 1.59640

Purity/Quality:

1H-BENZIMIDAZOLE, 3-OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,3-oxide(9CI)

There total 10 articles about 1H-Benzimidazole,3-oxide(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-Hydroxy-3H-benzoimidazol-1-ium; chloride → Benzimidazol-N-oxid (18916-43-3)

Guidance literature:

With ammonium hydroxide;

Reference yield:

N-(2-nitrophenyl)formamide (7418-32-8) → Benzimidazol-N-oxid (18916-43-3)

Guidance literature:

With sodium tetrahydroborate; palladium on activated charcoal; In pyridine; at 35 - 40 ℃; for 0.25h;

Reference yield:

2-nitro-aniline (88-74-4) → Benzimidazol-N-oxid (18916-43-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / cc. sulphuric acid, ZnCl₂ / acetic acid / 8 h / 50 °C

2: 54 percent / potassium carbonate / ethanol / 4 h / Heating

3: 57 percent / cc. HCl / 4 h

4: 68 percent / aq. NH₃

With hydrogenchloride; ammonium hydroxide; sulfuric acid; potassium carbonate; zinc(II) chloride; In ethanol; acetic acid;

upstream raw materials:

N-(2-nitrophenyl)formamide

n-(2-nitrophenyl)glycine ethyl ester

2-((2-nitrophenyl)amino)acetic acid

ethyl benzimidazole-2-carboxylate N-oxide

Downstream raw materials:

1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one

Refernces