Ethyl 2-[(2-nitrophenyl)amino]acetate

Base Information

• Chemical Name: Ethyl 2-[(2-nitrophenyl)amino]acetate
• CAS No.: 5428-05-7
• Molecular Formula: C10H12N2O4
• Molecular Weight: 224.216
• NSC Number: 12797
• DSSTox Substance ID: DTXSID50202633
• Nikkaji Number: J127.642E
• Wikidata: Q83075949

Synonyms:Ethyl 2-[(2-nitrophenyl)amino]acetate;5428-05-7;Ethyl 2-((2-nitrophenyl)amino)acetate;Ethyl N-(o-nitrophenyl)glycinate;GLYCINE, N-(o-NITROPHENYL)-, ETHYL ESTER;N-(o-Nitrophenyl)glycine ethyl ester;NSC 12797;BRN 2740408;Glycine, N-(2-nitrophenyl)-, ethyl ester;ethyl 2-(2-nitroanilino)acetate;NSC12797;DTXSID50202633;NSC-12797;N-(2-Nitrophenyl)glycine ethyl ester;AKOS008967476;Ethyl2-((2-nitrophenyl)amino)acetate;SB77303;BS-32543;LS-72776;CS-0209782;EN300-7360836;F1911-3529

Chemical Property of Ethyl 2-[(2-nitrophenyl)amino]acetate

Chemical Property:

• Vapor Pressure: 4.01E-05mmHg at 25°C
• Boiling Point: 351.8°C at 760 mmHg
• Flash Point: 166.6°C
• Density: 1.29g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 224.07970687
• Heavy Atom Count: 16
• Complexity: 252

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CNC1=CC=CC=C1[N+](=O)[O-]

Technology Process of Ethyl 2-[(2-nitrophenyl)amino]acetate

There total 6 articles about Ethyl 2-[(2-nitrophenyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diazoacetic acid ethyl ester (623-73-4) + 2-nitro-aniline (88-74-4) → n-(2-nitrophenyl)glycine ethyl ester (5428-05-7)

Guidance literature:

With 1-methylimidazolium tetrafluoroborate; In neat (no solvent); at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.08.013

Reference yield: 88.0%

ethanol (64-17-5) + 2-((2-nitrophenyl)amino)acetic acid (5427-99-6) → n-(2-nitrophenyl)glycine ethyl ester (5428-05-7)

Guidance literature:

With hydrogenchloride; Heating;

Reference yield: 85.0%

glycine ethyl ester hydrochloride (623-33-6) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → n-(2-nitrophenyl)glycine ethyl ester (5428-05-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 80h; Ambient temperature;

DOI:10.1021/jm00032a008

upstream raw materials:

ethyl bromoacetate

2-nitro-aniline

ethanol

2-((2-nitrophenyl)amino)acetic acid

Downstream raw materials:

2-((2-nitrophenyl)amino)acetic acid

4-(2-chlorophenyl)-1,2,3,4-tetrahydroquinoxalin-2-one

4-acetyl-3,4-dihydroquinoxalin-2(1H)-one

4-<(tert-butoxy)carbonyl>-1,2,3,4-tetrahydroquinoxalin-2-one

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