N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

Base Information

Chemical Name:N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide
CAS No.:1404059-62-6
Molecular Formula:C₂₄H₂₈FN₃O₅S
Molecular Weight:489.568
Hs Code.:

Synonyms:N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

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Chemical Property of N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

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Technology Process of N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

There total 5 articles about N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1404059-57-9
8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione

: 19040-62-1
2,5-dimethylbenzenesulfonyl chloride

: 1404059-62-6
N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1007/s00044-012-0265-x

Reference yield:

: 224309-64-2
tert-butyl N-(4-hydroxycyclohexyl)carbamate

: 1404059-62-6
N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 2 h / -78 °C

2: sodium cyanide / ethanol; water / 48 h / -78 - 50 °C

3: potassium carbonate / acetonitrile / 6 h / Reflux

4: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

5: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; sodium cyanide; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1007/s00044-012-0265-x

Reference yield:

: 179321-49-4
N-(tert-butoxycarbonyl)-4-aminocyclohexanone

: 1404059-62-6
N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2,5-dimethyl benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanide / ethanol; water / 48 h / -78 - 50 °C

2: potassium carbonate / acetonitrile / 6 h / Reflux

3: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

4: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; sodium cyanide; potassium carbonate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1007/s00044-012-0265-x