19040-62-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2,5-DIMETHYLBENZENESULFONYL CHLORIDE is used as a reagent for the production of pharmaceuticals, serving as an essential component in the synthesis of various medicinal compounds. Its sulfonating properties facilitate the formation of new chemical entities with potential therapeutic applications.
Used in Dye Production:
In the dye industry, 2,5-DIMETHYLBENZENESULFONYL CHLORIDE is employed as a reagent, contributing to the synthesis of dyes with specific color properties and stability. Its chemical structure allows for the creation of dyes with tailored characteristics for various applications.
Used in Polymer Synthesis:
2,5-DIMETHYLBENZENESULFONYL CHLORIDE is utilized as an intermediate in the synthesis of polymers, playing a crucial role in the development of materials with specific properties. Its ability to form sulfonyl linkages contributes to the creation of polymers with enhanced stability and functionality.
Used in Organic Compound Synthesis:
As an intermediate, 2,5-DIMETHYLBENZENESULFONYL CHLORIDE is used in the synthesis of other organic compounds, enabling the production of a wide range of chemical entities with diverse applications in various industries.
It is crucial to handle 2,5-DIMETHYLBENZENESULFONYL CHLORIDE with care due to its corrosive nature, which can cause severe skin and eye irritation upon contact. Proper safety measures should be taken to minimize potential hazards during its use in various applications.

Upstream product

• 609-54-1 2,5-dimethylbenzenesulfonic acid 
• 106-42-3 para-xylene 

Downstream Products

• 2548-26-7 2,5-dimethyldiphenyl sulfone 
• 4001-61-0 2,5-dimethylthiophenol 
• 2619-25-2 3-<2,5-Dimethyl-benzolsulfonylamino>-propionsaeurenitril 
• 66898-06-4 2,5-Dimethyl-N-(1-methyl-1-phenyl-ethyl)-benzenesulfonamide 
• 35293-51-7 1,4-dimethyl-2-thiocyanatobenzene 
• 3808-86-4 1,2-bis(2,5-dimethylphenyl)disulfane 
• 15310-87-9 (2,5-dimethyl-phenylsulfanyl)-acetic acid 
• 93-77-6 (4-chloro-2,5-dimethyl-phenylsulfanyl)-acetic acid 
• 71796-20-8 2,5-dimethyl-N-(4-chlorophenyl)benzenesulfonamide 
• 197960-04-6 3-(2,5-dimethylphenylsulfonyloxy)-5-methylphenol 
• 79851-92-6 7-[(2,5-Dimethylphenyl)Sulfonyl]-7H-Pyrrolo-[3,2-f]Quinazoline-1,3-Diamine 
• 1009077-34-2 isopropyl N-(2,5-xylylsulfonyl)propionimidate 
• 1009077-35-3 isopropyl N-(2,5-xylylsulfonyl)butyrimidate 
• 1009077-70-6 methyl N-(2,5-xylylsulfonyl)propionimidate 

Relevant academic research and scientific papers

Synthesis, biological evaluation, and enzyme assay of some 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines as potential anticancer agents

Thirty 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines were synthesized and evaluated biologically for their anticancer activities. The best active compound of this series showed 92.92% inhibition of tumor weight against Ehrlich Ascites Carcinoma cells. The most active compound was proved to be a competitive inhibitor of glutaminase in the enzyme assay. The best active compound may be a starting point to generate 'lead' for further exploration.

Propanolysis of arenesulfonyl chlorides: Nucleophilic substitution at sulfonyl sulfur

We have studied the mechanism of solvolysis of arenesulfonyl chlorides by propan-1-ol and propan-2-ol at 303-323 K. Kinetic profiles were appropriately fit by first-order kinetics. Reactivity increases with electron-donating substituents. Ortho-alkyl substituted derivatives of arenesulfonyl chlorides show increased reactivity, but the origin of this “positive” ortho-effect remains unclear. Likely, ortho-methyl groups restrict rotation around the C-S bond, facilitating the attack of the nucleophile. No relevant reactivity changes have been found with propan-1-ol and propan-2-ol in terms of nucleophile steric effect. The existence of isokinetic relationships for all substrates suggests a single mechanism for the series. Solvolysis reactions of all substrates in both alcohols show isokinetic temperatures (Tiso) close to the working temperature range, which is an evidence of the process being influenced by secondary reactivity factors, likely of steric nature in the TS. Solvation plays a relevant role in this reaction, modulating the reactivity. In some cases, the presence of t-Bu instead of Me in para- position leads to changes in the first solvation shell, increasing the energy of the reaction (ca. 1?kJ·mol?1). The obtained results suggest the same kinetic mechanism of solvolysis of arenesulfonyl chlorides for propan-1-ol and propan-2-ol, as in MeOH and EtOH, where bimolecular nucleophilic substitution (SN2) takes place with nucleophilic solvent assistance of one alcohol molecule and the participation of the solvent network involving solvent molecules of the first solvation shell.

Possible anticancer agents: synthesis, pharmacological activity, and molecular modeling studies on some 5-N -Substituted-2-N-(substituted benzenesulphonyl)-L(+)Glutamines

On the basis of our earlier work, fortyone 5-N-substituted-2N-(substituted benzenesulphonyl)-L(+)glutamines were synthesized and screened for cancer cell inhibitory activity. The best active compounds showed 91% tumor cell inhibition, whereas other three compounds showed more than 80% inhibition. Two-dimensional quantitative structure–activity relationship modeling and three-dimensional quantitative structure–activity relationship k-nearest neighbor molecular field analysis studies were done to get an insight into structural requirements toward further improved anticancer activity. Considering the fact that these compounds are competitive inhibitors of glutaminase, a molecular docking study followed by molecular dynamic simulation analysis were performed. The work may help to develop new anticancer agents.

PROCESS FOR PREPARING 1,1,3-TRIOXO-1,2-BENZOTHIAZOLE-6-CARBOXAMIDE

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III);

A new, mild preparation of sulfonyl chlorides

A new method was developed for the preparation of sulfonyl chlorides from sulfonic acids under neutral conditions using 2,4,6-trichloro-1,3,5-triazine as chlorinating agent.