N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester

Base Information

• Chemical Name: N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester
• CAS No.: 99532-92-0
• Molecular Formula: C₁₆H₂₄N₂O₄
• Molecular Weight: 308.378
• Mol file: 99532-92-0.mol

Synonyms:N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester

Chemical Property of N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester

There total 2 articles about N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methyl 2-[(tert-butoxycarbonyl)amino]acrylate (55477-80-0) + benzylamine (100-46-9) → Nα-<(tert-butyloxy)carbonyl>-Nβ-benzyldiaminopropionic acid methyl ester (99532-92-0)

Guidance literature:

In aq. phosphate buffer; N,N-dimethyl-formamide; at 37 ℃; for 4h; pH=8; Time;

DOI:10.1021/jacs.7b10702

Reference yield:

tert-butyl carbazate (4248-19-5) → Nα-<(tert-butyloxy)carbonyl>-Nβ-benzyldiaminopropionic acid methyl ester (99532-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / POCl₃ / benzene / 0.25 h / 70 °C

2: 64 percent / methanol / 45 °C

With trichlorophosphate; In methanol; benzene;

DOI:10.1021/jo00352a025

Reference yield: 100.0%

Nα-<(tert-butyloxy)carbonyl>-Nβ-benzyldiaminopropionic acid methyl ester (99532-92-0) → C11H16N2O2*ClH

Guidance literature:

N_α-<(tert-butyloxy)carbonyl>-N_β-benzyldiaminopropionic acid methyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With methanol; acetyl chloride; at 0 - 20 ℃; for 2h;

DOI:10.1021/jacs.7b10702

upstream raw materials:

methyl 2-[(tert-butoxycarbonyl)amino]acrylate

benzylamine

tert-butyl carbazate