(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Base Information

Chemical Name:(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate
CAS No.:1269619-53-5
Molecular Formula:C₄₉H₅₅N₃O₁₁
Molecular Weight:861.989
Hs Code.:

Synonyms:(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

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Chemical Property of (5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

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Technology Process of (5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

There total 10 articles about (5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1269619-48-8
dibenzyl 2-amino-6-((tertbutoxycarbonyl)amino)heptanedioate

: 204251-86-5
(R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(allyloxy)-5-oxopentanoic acid

: 1269619-53-5
(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Guidance literature:: With polystyrene bound carbodiimide; polystyrene bound DMAP; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm101535e

Reference yield:

: 1269619-44-4
(R)-1-allyl 5-tert-butyl 2-((tertbutoxycarbonyl)amino)pentanedioate

: 1269619-53-5
(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1 h

2: sodium carbonate / 1,4-dioxane; water / 10 - 20 °C

3: 1,4-dioxane; water / 16 h / 20 °C

4: polystyrene bound carbodiimide; polystyrene bound DMAP / dichloromethane / 4 h / 20 °C

With sodium carbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm101535e

Reference yield:

: 1227363-56-5
dibenzyl 2,6-bis((tert-butoxycarbonyl)amino)heptanedioate

: 1269619-53-5
(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 2 h

2: triethylamine / methanol / 0.5 h / pH 7

3: polystyrene bound carbodiimide; polystyrene bound DMAP / dichloromethane / 4 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm101535e