(5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Base Information

Chemical Name:(5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate
CAS No.:1269619-81-9
Molecular Formula:C₄₈H₅₅N₃O₁₁
Molecular Weight:849.978
Hs Code.:

Synonyms:(5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

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Chemical Property of (5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

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Technology Process of (5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

There total 13 articles about (5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 64-17-5
ethanol

: C₄₉H₅₇N₃O₁₁

: 1269619-81-9
(5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Guidance literature:: With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm101535e

Reference yield:

: 1269619-53-5
(5R)-5-allyl 10,14-dibenzyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

: 1269619-81-9
(5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Wilkinson's catalyst / ethanol; water / 3 h / 90 °C

2: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 14 h / 20 °C

With dmap; Wilkinson's catalyst; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm101535e

Reference yield:

: 1269619-44-4
(R)-1-allyl 5-tert-butyl 2-((tertbutoxycarbonyl)amino)pentanedioate

: 1269619-81-9
(5R)-10,14-dibenzyl 5-ethyl-1-(9H-fluoren-9-yl)-18,18-dimethyl-3,8,16-trioxo-2,17-dioxa-4,9,15-triazanonadecane-5,10,14-tricarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1 h

2: sodium carbonate / 1,4-dioxane; water / 10 - 20 °C

3: 1,4-dioxane; water / 16 h / 20 °C

4: polystyrene bound carbodiimide; polystyrene bound DMAP / dichloromethane / 4 h / 20 °C

5: Wilkinson's catalyst / ethanol; water / 3 h / 90 °C

6: dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 14 h / 20 °C

With dmap; Wilkinson's catalyst; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm101535e