tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate
CAS No.:1611481-03-8
Molecular Formula:C₁₈H₂₅FN₂O₄
Molecular Weight:352.406
Hs Code.:

Synonyms:tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

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Chemical Property of tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

There total 16 articles about tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1593969-81-3
tert-butyl N-[(3S,5S)-5-fluoropiperidin-3-yl]carbamate

: 100-07-2
4-methoxy-benzoyl chloride

: 1611481-03-8
tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.201302423

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1611481-03-8
tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / 14 h / 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / water; ethanol / 1.5 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; diethylamino-sulfur trifluoride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1002/chem.201302423

Reference yield:

: 1318129-73-5
methyl (2R,4R)-4-hydroxy-1-(4-methoxybenzyl)pyrrolidine-2-carboxylate

: 1611481-03-8
tert-butyl (3S,5S)-5-fluoro-1-(4-methoxybenzoyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 14 h / 0 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 22 h / 20 - 65 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

4: 1,4-dioxane / 20 h / 20 °C / Inert atmosphere

5: diethylamino-sulfur trifluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6: palladium 10% on activated carbon; formic acid; piperidine / methanol; water / 1 h / 55 °C / Inert atmosphere; Microwave irradiation

7: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With piperidine; lithium aluminium tetrahydride; formic acid; sodium azide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201302423