3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

Base Information

Chemical Name:3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester
CAS No.:870195-35-0
Molecular Formula:C₁₆H₁₉ClO₅
Molecular Weight:326.777
Hs Code.:

Synonyms:3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

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Chemical Property of 3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

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Technology Process of 3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

There total 4 articles about 3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 870194-52-8
(3-chloro-4-formylphenyl)acetic acid methyl ester

: 35059-50-8
t-butyl diazoacetate

: 870195-35-0
3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

Guidance literature:: With tin(ll) chloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.08.052

Reference yield:

: 57017-95-5
methyl 3-chloro-4-hydroxyphenylacetate

: 870195-35-0
3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide) / 34 h / 80 °C

3: Raney-alloy / 10 h / 110 °C

4: tin(ll) chloride / dichloromethane / 6 h / 20 °C

With Raney-alloy; triethylamine; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); dichloromethane;

Reference yield:

: 496856-45-2
(3-chloro-4-cyanophenyl)acetic acid methyl ester

: 870195-35-0
3-(2-chloro-4-methoxycarbonylmethylphenyl)-3-oxopropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Raney-alloy / 10 h / 110 °C

2: tin(ll) chloride / dichloromethane / 6 h / 20 °C

With Raney-alloy; tin(ll) chloride; In dichloromethane;