*,R^*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: *,R^*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate
• CAS No.: 101250-83-3
• Molecular Formula: C₂₅H₃₉N₃O₅
• Molecular Weight: 461.602

Synonyms:*,R^*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Chemical Property of *,R^*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Chemical Property:

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Technology Process of *,R^*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

There total 5 articles about *,R^*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Glycine tert-butyl ester (6456-74-2) → *,R*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 1H-benzotriazol-1-ol (HOBT), DCC / tetrahydrofuran / 18 h / 25 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

(S)-2-(2-Methylpropyl)-aziridine (23852-57-5) → *,R*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-83-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 90.5 percent / Et₃N / diethyl ether / 1 h / 0 °C

2: 17.6 g / ethanol / 48 h / Heating

3: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

4: 1H-benzotriazol-1-ol (HOBT), DCC / tetrahydrofuran / 18 h / 25 °C

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol;

DOI:10.1021/jm00156a012

Reference yield:

(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate (101250-56-0) → *,R*)>-phenylmethyl 2-<<<2-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 1H-benzotriazol-1-ol (HOBT), DCC / tetrahydrofuran / 18 h / 25 °C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00156a012

upstream raw materials:

((S)-2-Amino-4-methyl-pentylamino)-acetic acid tert-butyl ester

N-Benzyloxycarbonyl-L-proline

Glycine tert-butyl ester

(S)-2-(2-Methylpropyl)-aziridine

Downstream raw materials:

*,R^*)>-phenylmethyl 2-<<<1-<<(2-amino-2-oxoethyl)amino>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

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