(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

Base Information

Chemical Name:(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate
CAS No.:101250-56-0
Molecular Formula:C₁₄H₁₉NO₂
Molecular Weight:233.31
Hs Code.:

Synonyms:(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

Chemical Property:

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Technology Process of (S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

There total 1 articles about (S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 23852-57-5
(S)-2-(2-Methylpropyl)-aziridine

: 501-53-1,94274-21-2
benzyl chloroformate

: 101250-56-0
(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

Guidance literature:: With triethylamine; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/jm00156a012

Reference yield:

: 101250-56-0
(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

: 104379-74-0
[tert-Butoxycarbonyl-((S)-4-methyl-2-{[(S)-1-(toluene-4-sulfonyl)-pyrrolidin-2-ylmethyl]-amino}-pentyl)-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 2.) 5A molecular sieves, 2.) bromcresol, NaCNBH₃

With 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00156a012

Reference yield:

: 101250-56-0
(S)-phenylmethyl 2-(2-methylpropyl)-1-aziridinecarboxylate

: 101250-07-1
*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)amino>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 17.6 g / ethanol / 48 h / Heating

2: H₂ / 20percent Pd/C / methanol / 2585.7 Torr

3: 2.) 5A molecular sieves, 2.) NaCNBH₃, bromcresol, HCl gas

4: trifluoroacetic acid (TFA)

With hydrogenchloride; 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen; sodium cyanoborohydride; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1021/jm00156a012