4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

Base Information

Chemical Name:4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone
CAS No.:406196-68-7
Molecular Formula:C₁₉H₁₀Cl₂N₂O₂S
Molecular Weight:401.273
Hs Code.:

Synonyms:4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

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Chemical Property of 4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

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Technology Process of 4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

There total 6 articles about 4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 406196-67-6
2,2,2-trichloro-N-[2-(3-chlorobenzoyl)-4-[(5-chloro-2-thienyl)carbonyl]phenyl]acetamide

: 406196-68-7
4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

Guidance literature:: With ammonium acetate; In dimethyl sulfoxide; at 60 ℃; for 4h;
DOI:10.1016/j.ejmech.2006.12.007

Reference yield:

: 7283-96-7
5-Chloro-2-thiophenecarboxaldehyde

: 406196-68-7
4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -70 °C

1.2: 68 percent / tetrahydrofuran; hexane / 1 h / -70 °C

2.1: 64 percent / MnO₂ / dioxane / 15 h / Heating

3.1: 100 percent / aq. TiCl₃ / tetrahydrofuran / 3 h / 20 °C

4.1: 100 percent / Et₃N / CH₂Cl₂ / 20 °C

5.1: 83 percent / ammonium acetate / dimethylsulfoxide / 4 h / 60 °C

With ammonium acetate; manganese(IV) oxide; n-butyllithium; titanium(III) chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2006.12.007

Reference yield:

: 943834-86-4
[3-(3-chlorophenyl)-1,2-benzisoxazol-5-yl](5-chloro-2-thienyl)methanone

: 406196-68-7
4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. TiCl₃ / tetrahydrofuran / 3 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 20 °C

3: 83 percent / ammonium acetate / dimethylsulfoxide / 4 h / 60 °C

With ammonium acetate; titanium(III) chloride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2006.12.007