[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

Base Information

Chemical Name:[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone
CAS No.:406196-69-8
Molecular Formula:C₁₉H₉Cl₃N₂OS
Molecular Weight:419.718
Hs Code.:

Synonyms:[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

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Chemical Property of [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

Chemical Property:

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Technology Process of [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

There total 7 articles about [2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 406196-68-7
4-(3-chlorophenyl)-6-[(5-chloro-2-thienyl)carbonyl]-2(1H)-quinazolinone

: 406196-69-8
[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

Guidance literature:: With trichlorophosphate; at 100 ℃; for 2h;
DOI:10.1016/j.ejmech.2006.12.007

Reference yield:

: 7283-96-7
5-Chloro-2-thiophenecarboxaldehyde

: 406196-69-8
[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -70 °C

1.2: 68 percent / tetrahydrofuran; hexane / 1 h / -70 °C

2.1: 64 percent / MnO₂ / dioxane / 15 h / Heating

3.1: 100 percent / aq. TiCl₃ / tetrahydrofuran / 3 h / 20 °C

4.1: 100 percent / Et₃N / CH₂Cl₂ / 20 °C

5.1: 83 percent / ammonium acetate / dimethylsulfoxide / 4 h / 60 °C

6.1: 88 percent / POCl₃ / 2 h / 100 °C

With ammonium acetate; manganese(IV) oxide; n-butyllithium; titanium(III) chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2006.12.007

Reference yield:

: 943834-86-4
[3-(3-chlorophenyl)-1,2-benzisoxazol-5-yl](5-chloro-2-thienyl)methanone

: 406196-69-8
[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](5-chloro-2-thienyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / aq. TiCl₃ / tetrahydrofuran / 3 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 20 °C

3: 83 percent / ammonium acetate / dimethylsulfoxide / 4 h / 60 °C

4: 88 percent / POCl₃ / 2 h / 100 °C

With ammonium acetate; titanium(III) chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2006.12.007