<1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide

Base Information

• Chemical Name: <1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide
• CAS No.: 175979-80-3
• Molecular Formula: C₂₃H₃₁NO₃
• Molecular Weight: 369.504
• Mol file: 175979-80-3.mol

Synonyms:<1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide

Chemical Property of <1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of <1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide

There total 1 articles about <1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1,2-epoxypropane (558-30-5) + N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide (14980-86-0,42407-58-9) → <1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide (175979-80-3)

Guidance literature:

With lithium chloride; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 -> 23 deg C, 2.) THF, 0 deg C, 4 h;

DOI:10.1021/jo952032o

Reference yield: 94.0%

<1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide (175979-80-3) → (S)-3-Benzyl-5,5-dimethyl-dihydro-furan-2-one (175979-81-4)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; water; at 95 ℃; for 2h;

DOI:10.1021/jo952032o

Reference yield:

<1S(2S),2S>-N-(2-hydroxy-1-methyl-2-phenylethyl)-4-hydroxy-N,4-dimethyl-2-(phenylmethyl)pentanamide (175979-80-3) → (S)-2-Benzyl-4-methyl-pentane-1,4-diol

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / sulfuric acid / H₂O; dioxane / 2 h / 95 °C

2: lithium aluminum hydride / diethyl ether / 0 °C

With lithium aluminium tetrahydride; sulfuric acid; In 1,4-dioxane; diethyl ether; water;

DOI:10.1021/jo952032o

upstream raw materials:

2-methyl-1,2-epoxypropane

N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide

Downstream raw materials:

(S)-3-Benzyl-5,5-dimethyl-dihydro-furan-2-one