Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Base Information

Chemical Name:Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate
CAS No.:1234619-69-2
Molecular Formula:C₂₄H₁₈F₃N₇O₄S
Molecular Weight:557.513
Hs Code.:

Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Synonyms:Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

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Chemical Property of Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

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Technology Process of Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

There total 11 articles about Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1234619-38-5
(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 79-22-1
methyl chloroformate

: 1234619-69-2
Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 - 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 170572-49-3
2-fluoro-4-cyanotoluene

: 1234619-69-2
Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N,N-dimethyl-formamide / 20 °C / Heating

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 10 - 20 °C

3.1: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

4.1: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

5.1: piperidine; acetic acid / dichloromethane / 18 h / Reflux

6.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

7.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

8.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

9.1: triethylamine; pyridine; copper diacetate / dichloromethane / 12 h / Inert atmosphere; Molecular sieve

9.2: 84 h / Inert atmosphere

9.3: 120 h

10.1: hydrazine hydrate / ethanol / 1 h / 85 °C

11.1: pyridine / tetrahydrofuran / 12 h / 20 - 80 °C / Inert atmosphere

With piperidine; pyridine; sodium periodate; copper diacetate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; rac-Pro-OH; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1161921-93-2
4-formyl-3-(methylsulfonyl)benzonitrile

: 1234619-69-2
Methyl {6-cyano-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine; acetic acid / dichloromethane / 18 h / Reflux

2.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

3.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

4.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

5.1: triethylamine; pyridine; copper diacetate / dichloromethane / 12 h / Inert atmosphere; Molecular sieve

5.2: 84 h / Inert atmosphere

5.3: 120 h

6.1: hydrazine hydrate / ethanol / 1 h / 85 °C

7.1: pyridine / tetrahydrofuran / 12 h / 20 - 80 °C / Inert atmosphere

With piperidine; pyridine; copper diacetate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; rac-Pro-OH; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;