(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Name:(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234619-38-5
Molecular Formula:C₂₂H₁₆F₃N₇O₂S
Molecular Weight:499.476
Hs Code.:

(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Synonyms:(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

There total 10 articles about (rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1234619-35-2
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

: 1234619-38-5
(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile; With hydrazine hydrate; In ethanol; at 85 ℃; for 1h;

With hydrogenchloride; In water; N,N-dimethyl-formamide;

Reference yield:

: 170572-49-3
2-fluoro-4-cyanotoluene

: 1234619-38-5
(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: N,N-dimethyl-formamide / 20 °C / Heating

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 10 - 20 °C

3.1: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

4.1: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

5.1: piperidine; acetic acid / dichloromethane / 18 h / Reflux

6.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

7.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

8.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

9.1: triethylamine; pyridine; copper diacetate / dichloromethane / 12 h / Inert atmosphere; Molecular sieve

9.2: 84 h / Inert atmosphere

9.3: 120 h

10.1: hydrazine hydrate / ethanol / 1 h / 85 °C

With piperidine; pyridine; sodium periodate; copper diacetate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; rac-Pro-OH; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1161921-93-2
4-formyl-3-(methylsulfonyl)benzonitrile

: 1234619-38-5
(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: piperidine; acetic acid / dichloromethane / 18 h / Reflux

2.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

3.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

4.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

5.1: triethylamine; pyridine; copper diacetate / dichloromethane / 12 h / Inert atmosphere; Molecular sieve

5.2: 84 h / Inert atmosphere

5.3: 120 h

6.1: hydrazine hydrate / ethanol / 1 h / 85 °C

With piperidine; pyridine; copper diacetate; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid; triethylamine; rac-Pro-OH; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;